منابع مشابه
Pharmacology and functions of metabotropic glutamate receptors.
In the mid to late 1980s, studies were published that provided the first evidence for the existence of glutamate receptors that are not ligand-gated cation channels but are coupled to effector systems through GTP-binding proteins. Since those initial reports, tremendous progress has been made in characterizing these metabotropic glutamate receptors (mGluRs), including cloning and characterizati...
متن کاملThe biochemical pharmacology of metabotropic glutamate receptors.
11. Geoffroy, M., Lambolez, B., Audinat, E., Hamon, B., Crepe], F., Rossier, J. and Kado, R. T. (1991) Mol. Pharmacol. 39,587-591 12. Lambolez, B., Audinat, E., Bochet, P., Crepe], F. and Rossier, J. (1992) Neuron 9,247-258 Gilliland, G., Perrin, S. and Bunn, F. H. (1990) in PCR Protocols (Innis, M. A., Gelfand, D. H., Sninsky, J. J. and White, T. G., eds.), pp. 60-69, Academic Press, NY Wang, ...
متن کاملGlutamate Receptors; from Basic Pharmacology to Clinical Applications
The existence of glutamate receptors as important neurotransmitter receptors was not fully accepted until the 1980s. It is now generally agreed that glutamate is the major fast excitatory neurotransmitter in brain, and plays a major role in brain development, affecting neuronal migration, neuronal differentiation, axon genesis, and neuronal survival through its action on the glutamate receptors...
متن کاملPreface Introduction to Glutamate Receptors , Their Function and Pharmacology
In the 1970s and 1980s a neurotransmitter role for glutamate, previously considered to be solely a metabolic precursor, was finally accepted (112,119). It is now generally agreed that glutamate is the major fast excitatory neurotransmitter in brain. In fact, it is believed that 70% of the excitatory central nervous system (CNS) synapses utilize glutamate as a transmitter. Glutamate is probably ...
متن کاملPharmacology and Structural Analysis of Ligand Binding to the Orthosteric Site of Glutamate-Like GluD2 Receptors.
The GluD2 receptor is a fundamental component of postsynaptic sites in Purkinje neurons, and is required for normal cerebellar function. GluD2 and the closely related GluD1 are classified as members of the ionotropic glutamate receptor (iGluR) superfamily on the basis of sequence similarity, but do not bind l-glutamate. The amino acid neurotransmitter D-Ser is a GluD2 receptor ligand, and endog...
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ژورنال
عنوان ژورنال: Japanese Journal of Pharmacology
سال: 2000
ISSN: 0021-5198
DOI: 10.1016/s0021-5198(19)47502-1